Two related studies are briefly described below.
1. Retinal ganglion cells directly project to dorsal raphe nucleus (DRN) and regulate depressive symptoms DRN is the main 5-hydroxytryptamine (5-HT) center in the brain, and 5-HT is closely related to depression: the main The antidepressants SSRI are selective serotonin reuptake inhibitors.
The direct projection from the retina to the DRN, this magical pathway was discovered by Pu Mingliang's group at Peking University Health Science Center.
Guangdong Jishengke Industrial Co., Ltd. was established in 2013, has 8 years of manufacturing and exporting experience, and currently has more than 100 employees. It is an enterprise with independent research and development of core technology and capabilities, and is a well-known manufacturer of LED Light Pad, Tracing Light Box, SAD Lamp, Drawing Tablet products, etc. If you are interested in our products, please contact us.
2. Retinal-raphe nucleus connection regulates serotonin activity and defensive behavior against visual danger (looming) This 2017 research technology has advanced a lot (mainly because there are more mouse tools at once...).
It was first found by viral means that RGC-DRN projections were almost exclusively to GABA neurons rather than 5-HT neurons. GABA is an inhibitory neurotransmitter, and GABA neurons within the DRN have a wide range of projections that also include inhibition of local 5-HT neurons.
Looming stimulus refers to when there is a rapidly approaching object above the visual field of the mouse. This is because the appearance of a rapidly approaching predator triggers innate defensive behavior (hide!).